Browsing by Author "Grossmann, Nicolas"

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    Lessons Learnt from Developing Visual Analytics Applications for Adaptive Prostate Cancer Radiotherapy
    (The Eurographics Association, 2020) Raidou, Renata Georgia; Furmanová, Katarína; Grossmann, Nicolas; Casares-Magaz, Oscar; Moiseenko, Vitali; Einck, John P.; Gröller, Eduard; Muren, Ludvig P.; Gillmann, Christina and Krone, Michael and Reina, Guido and Wischgoll, Thomas
    In radiotherapy (RT), changes in patient anatomy throughout the treatment period might lead to deviations between planned and delivered dose, resulting in inadequate tumor coverage and/or overradiation of healthy tissues. Adapting the treatment to account for anatomical changes is anticipated to enable higher precision and less toxicity to healthy tissues. Corresponding tools for the in-depth exploration and analysis of available clinical cohort data were not available before our work. In this paper, we discuss our on-going process of introducing visual analytics to the domain of adaptive RT for prostate cancer. This has been done through the design of three visual analytics applications, built for clinical researchers working on the deployment of robust RT treatment strategies. We focus on describing our iterative design process, and we discuss the lessons learnt from our fruitful collaboration with clinical domain experts and industry, interested in integrating our prototypes into their workflow.
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    Pelvis Runner: Visualizing Pelvic Organ Variability in a Cohort of Radiotherapy Patients
    (The Eurographics Association, 2019) Grossmann, Nicolas; Casares-Magaz, Oscar; Muren, Ludvig Paul; Moiseenko, Vitali; Einck, John P.; Gröller, Eduard; Raidou, Renata Georgia; Kozlíková, Barbora and Linsen, Lars and Vázquez, Pere-Pau and Lawonn, Kai and Raidou, Renata Georgia
    In radiation therapy, anatomical changes in the patient might lead to deviations between the planned and delivered dose- including inadequate tumor coverage, and overradiation of healthy tissues. Exploring and analyzing anatomical changes throughout the entire treatment period can help clinical researchers to design appropriate treatment strategies, while identifying patients that are more prone to radiation-induced toxicity. We present the Pelvis Runner, a novel application for exploring the variability of segmented pelvic organs in multiple patients, across the entire radiation therapy treatment process. Our application addresses (i) the global exploration and analysis of pelvic organ shape variability in an abstracted tabular view and (ii) the local exploration and analysis thereof in anatomical 2D/3D views, where comparative and ensemble visualizations are integrated. The workflow is based on available retrospective cohort data, which incorporate segmentations of the bladder, the prostate, and the rectum through the entire radiation therapy process. The Pelvis Runner is applied to four usage scenarios, which were conducted with two clinical researchers, i.e., medical physicists. Our application provides clinical researchers with promising support in demonstrating the significance of treatment plan adaptation to anatomical changes.