Barrio: Customizable Spatial Neighborhood Analysis and Comparison for Nanoscale Brain Structures

Troidl, Jakob; Cali, Corrado; Gröller, Eduard; Pfister, Hanspeter; Hadwiger, Markus; Beyer, Johanna

Barrio: Customizable Spatial Neighborhood Analysis and Comparison for Nanoscale Brain Structures

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v41i3pp183-194.pdf (5 MB)

1076-file1.pdf (4.27 MB)

1076-file2.mp4 (55.3 MB)

Date

2022

Authors

Troidl, Jakob
Cali, Corrado
Gröller, Eduard
Pfister, Hanspeter
Hadwiger, Markus
Beyer, Johanna

Publisher

The Eurographics Association and John Wiley & Sons Ltd.

Abstract

High-resolution electron microscopy imaging allows neuroscientists to reconstruct not just entire cells but individual cell substructures (i.e., cell organelles) as well. Based on these data, scientists hope to get a better understanding of brain function and development through detailed analysis of local organelle neighborhoods. In-depth analyses require efficient and scalable comparison of a varying number of cell organelles, ranging from two to hundreds of local spatial neighborhoods. Scientists need to be able to analyze the 3D morphologies of organelles, their spatial distributions and distances, and their spatial correlations. We have designed Barrio as a configurable framework that scientists can adjust to their preferred workflow, visualizations, and supported user interactions for their specific tasks and domain questions. Furthermore, Barrio provides a scalable comparative visualization approach for spatial neighborhoods that automatically adjusts visualizations based on the number of structures to be compared. Barrio supports small multiples of spatial 3D views as well as abstract quantitative views, and arranges them in linked and juxtaposed views. To adapt to new domain-specific analysis scenarios, we allow the definition of individualized visualizations and their parameters for each analysis session. We present an in-depth case study for mitochondria analysis in neuronal tissue and demonstrate the usefulness of Barrio in a qualitative user study with neuroscientists.

CCS Concepts: Human-Centered Computing --> Spatial neighborhood analysis, Visual comparisons, Neuroscience, Scientific visualization

        @article{10.1111:cgf.14532
,
journal = {Computer Graphics Forum},
title = {{Barrio: Customizable Spatial Neighborhood Analysis and Comparison for Nanoscale Brain Structures
}},
author = {Troidl, Jakob and 
Cali, Corrado and 
Gröller, Eduard and 
Pfister, Hanspeter and 
Hadwiger, Markus and 
Beyer, Johanna
},
year = {2022
},
publisher = {The Eurographics Association and John Wiley & Sons Ltd.
},
ISSN = {1467-8659
},
DOI = {10.1111/cgf.14532
}
}